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1 ---------------------------- OMB APPROVAL OMB Number: 3235-0145 Expires: December 31, 1997 Estimated average burden hours per response. . .14.90 ---------------------------- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT)* Alexion Pharmaceuticals, Inc. - -------------------------------------------------------------------------------- (Name of Issuer) Common Stock ($.0001 par value) - -------------------------------------------------------------------------------- (Title of Class of Securities) 015351109 ------------------------------ (CUSIP Number) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). 2 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 2 OF 17 --------- --- ---- - ------------------------- ------------------------------ - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON BIOTECHNOLOGY INVESTMENT GROUP, LLC ("BIO") S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -0- NUMBER OF ------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 891,898 EACH ------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH -0- ------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 891,898 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 891,898 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* 00 - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! 3 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 3 OF 17 --------- --- ---- - ------------------------- ------------------------------ - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON EDWARD BLECH TRUST ("EBT") S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a)[ ] (b)[ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION New York - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -0- NUMBER OF ------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 891,898 EACH ------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH -0- ------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 891,898 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 891,898 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* OO - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! 4 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 4 OF 17 --------- --- ---- - ------------------------- ------------------------------ - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON COLLINSON HOWE VENTURE PARTNERS, INC. S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -0- NUMBER OF ------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 891,898 EACH ------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH -0- ------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 891,898 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 891,898 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* CO - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! 5 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 5 OF 17 --------- --- ---- - ------------------------- ------------------------------ - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON SCHRODERS INCORPORATED ("SI") S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -0- NUMBER OF ------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 891,898 EACH ------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH -0- ------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 891,898 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 891,898 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* CO - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! 6 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 6 OF 17 --------- --- ---- - ------------------------- ------------------------------ - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON JEFFREY J. COLLINSON ("JJC") S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER 7,131 NUMBER OF ------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 899,029 EACH ------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH 7,131 ------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 899,029 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 899,029 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.2% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! 7 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 7 OF 17 --------- --- ---- - ------------------------- ------------------------------ - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON SCHRODER VENTURES U.S. TRUST ("SVUST") S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Bermuda - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -0- NUMBER OF ------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 891,898 EACH ------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH -0- ------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 891,898 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 891,898 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* OO - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! 8 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 8 OF 17 --------- --- ---- - ------------------------- ------------------------------ - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON SCHRODER VENTURES LIMITED PARTNERSHIP ("SVLP") S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON N/A - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -0- NUMBER OF ------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 891,898 EACH ------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH -0- ------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 891,898 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 891,898 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT! 9 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 9 OF 17 --------- --- ---- - ------------------------- ------------------------------ ITEM 1(a). NAME OF ISSUER: Alexion Pharmaceuticals, Inc. --------------- ITEM 1(b). ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES: ------------------------------------------------ 25 Science Park New Haven, CT 06511 ITEM 2. NAMES, ADDRESSES AND CITIZENSHIP OF PERSONS FILING: -------------------------------------------------- I. For Reporting Person -------------------- BIOTECHNOLOGY INVESTMENT GROUP, L.L.C.: a) Biotechnology Investment Group, L.L.C. b) c/o Collinson Howe Venture Partners, Inc. 1055 Washington Boulevard Stamford, CT 06901 c) Place of organization -- Delaware II. REGARDING REPORTING PERSON EDWARD BLECH TRUST: a) Edward Blech Trust b) 418 Avenue I Brooklyn, NY 11231 c) Trusted created under laws of New York REGARDING REPORTING PERSON COLLINSON HOWE VENTURE PARTNERS, INC. a) Collinson Howe Venture Partners, Inc. b) 1055 Washington Boulevard Stamford, CT 06901 c) Place of Organization - Delaware REGARDING REPORTING PERSON: a) Schroders Incorporated b) 787 Seventh Avenue, 29th Floor New York, NY 10019 c) Place of Organization -- Delaware 10 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 10 OF 17 --------- ---- ---- - ------------------------- ------------------------------ REGARDING REPORTING PERSON JEFFREY J. COLLINSON: a) Jeffrey J. Collinson b) 1055 Washington Boulevard, Stamford, CT 06901 c) Citizenship - United States REGARDING REPORTING PERSON SCHRODER VENTURES US TRUST: a) Schroder Ventures U.S. Trust b) c/o Schroder Venture Managers Limited 22 Church Street Hamilton HM 11, Bermuda c) SVUST is a closed-end unit trust created under the laws of Bermuda REGARDING REPORTING PERSON SCHRODER VENTURES LIMITED PARTNERSHIP: a) Schroder Ventures Limited Partnership b) c/o Schroder Ventures Management L.P. 787 Seventh Avenue 29th Floor New York, NY 10019 c) Place of organization -- Delaware ITEM 2(d). TITLE OF CLASS OF SECURITIES: Common Stock ----------------------------- ITEM 2(e). CUSIP NUMBER: N/A ------------- ITEM 3. IF THIS STATEMENT IF FILED PURSUANT TO RULES -------------------------------------------- 13D-1(b), or 13D-2(b), CHECK WHETHER THE PERSON FILING IS A: ------------------------------------------------------------ (a) [ ] Broker or Dealer registered under Section 15 of the Act, (b) [ ] Bank as defined in Section 3(a)(6) of the Act, (c) [ ] Insurance Company as defined in Section 3(a)(19) of the Act, (d) [ ] Investment Company registered under Section 8 of the Investment Company Act, (e) [ ] Investment Advisor registered under Section 203 of the Investment Advisors Act of 1940, (f) [ ] Employee Benefit Plan, Pension Fund which is subject to the provisions of the Employee Retirement Income Security Act of 1974 or Endowment Fund; see Rule 13d-1(b)(1)(ii)(f) of the Act, (g) [ ] Parent Holding Company, in accordance with Rule 13d-1(b)(ii)(G); see Item 7, 11 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 11 OF 17 --------- ---- ---- - ------------------------- ------------------------------ (h) [ ] Group, in accordance with Rule 13d-1(b)(l)(ii)(H). Not Applicable. ITEM 4. OWNERSHIP. --------- See Items 5-8 on cover pages. ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS. -------------------------------------------- Not Applicable. ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER -------------------------------------------------------- PERSON. ------ Not Applicable. ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH --------------------------------------------------------- ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING ------------------------------------------------------------- COMPANY. ------- Not Applicable. ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP. ---------------------------------------------------------- Not applicable. ITEM 9. NOTICE OF DISSOLUTION OF GROUP. ------------------------------- Not Applicable. ITEM 10. CERTIFICATION. -------------- Not Applicable. This statement on Schedule 13G is not filed pursuant to Rule 13d-1(b). 12 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 12 OF 17 --------- ---- ---- - ------------------------- ------------------------------ SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. February 28, 1997 BIOTECHNOLOGY INVESTMENT GROUP, L.L.C. ----------------- By: COLLINSON HOWE VENTURE PARTNERS, INC. Date Its: Managing Member By: * -------------------------------------------- Jeffrey J. Collinson, President EDWARD BLECH TRUST By: * -------------------------------------------- Mordechai Jofen, as Sole Trustee COLLINSON HOWE VENTURE PARTNERS, INC. By: * -------------------------------------------- Jeffrey J. Collinson, President * ----------------------------------------------- JEFFREY J. COLLINSON SCHRODERS INCORPORATED By: * -------------------------------------------- Jeffrey J. Collinson, Its Attorney-in-Fact SCHRODER VENTURES U.S. TRUST By: SCHRODER VENTURE MANAGERS LIMITED Its: Manager By: * -------------------------------------------- 13 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 13 OF 17 --------- ---- ---- - ------------------------- ------------------------------ SCHRODER VENTURES LIMITED PARTNERSHIP By: SCHRODER VENTURES MANAGEMENT L.P. Its: General Partner By: SCHRODER VENTURE MANAGERS INC. Its: General Partner By: * -------------------------------------------- * By: /s/Timothy C. Maguire -------------------------------------------- Timothy C. Maguire, Attorney-in-Fact 14 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 14 OF 17 --------- ---- ---- - ------------------------- ------------------------------ EXHIBIT 1 --------- AGREEMENT --------- Pursuant to Rule 13d-1(f)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed on behalf of all of the undersigned with respect to the ownership of shares of Common Stock of Alexion Pharmaceuticals, Inc. by any of the undersigned. This agreement may be executed in any number of counterparts, each of which shall be deemed an original. EXECUTED as a sealed instrument this 28th day of February, 1997. BIOTECHNOLOGY INVESTMENT GROUP, L.L.C. By:COLLINSON HOWE VENTURE PARTNERS, INC. Its: Managing Member By: /s/Jeffrey J. Collinson --------------------------------- Jeffrey J. Collinson, President EDWARD BLECH TRUST By: /s/Mordechai Jofen --------------------------------- Mordechai Jofen, as Sole Trustee COLLINSON HOWE VENTURE PARTNERS, INC. By: /s/Jeffrey J. Collinson --------------------------------- Jeffrey J. Collinson, President /s/Jeffrey J. Collinson --------------------------------- JEFFREY J. COLLINSON SCHRODERS INCORPORATED By: /s/Jeffrey J. Collinson --------------------------------- Jeffrey J. Collinson Its: Attorney-in-Fact SCHRODER VENTURES U.S. TRUST By: SCHRODER VENTURE MANAGERS LIMITED Its: Manager By: /s/Peter Everson --------------------------------- Peter Everson 15 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 15 OF 17 --------- ---- ---- - ------------------------- ------------------------------ SCHRODER VENTURES LIMITED PARTNERSHIP By: SCHRODER VENTURES MANAGEMENT L.P. Its: General Partner By: SCHRODER VENTURE MANAGERS INC. Its: General Partner By: /s/Peter Everson ------------------------------------ Peter Everson 16 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 16 OF 17 --------- ---- ---- - ------------------------- ------------------------------ Exhibit 2 --------- POWER OF ATTORNEY KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below, and each entity for which an authorized signature appears below, hereby constitutes and appoints Timothy C. Maguire and Anne G. Plimpton, and each of them, each with full power to act without the other, his, her or its, as the case may be, true and lawful attorney-in-fact, with full power of substitution, to sign any and all instruments, certificates and documents that may be necessary, desirable or appropriate to be executed on behalf of himself, herself or itself, as the case may be, as an individual or in his, her or its, as the case may be, capacity as a general partner of any partnership or a trustee of any trust, pursuant to section 13 or 16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and any and all regulations promulgated thereunder, and to file the same, with all exhibits thereto, and any other documents in connection therewith, all in connection with the beneficial ownership of securities held by the undersigned, with the Securities and Exchange Commission, and with any other entity when and if such is mandated by the Exchange Act or by the By-laws of the National Association of Securities Dealers, Inc., granting unto said attorney-in-fact full power and authority to do and perform each and every act and thing necessary, desirable or appropriate, fully to all intents and purposes as he might or could do in person, thereby ratifying and confirming all that said attorney-in-fact, or his substitutes, may lawfully do or cause to be done by virtue hereof. This Power of Attorney will remain in effect until revoked by an instrument in writing delivered to the aforesaid attorney(s)-in-fact. The undersigned each acknowledge that Timothy C. Maguire and Anne G. Plimpton are not assuming any of the undersigned's responsibilities to comply with Section 16 of the Securities Exchange Act of 1934. IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 12th day of February, 1997. BIOTECHNOLOGY INVESTMENT GROUP, L.L.C. By: COLLINSON HOWE VENTURE PARTNERS, INC. Its: Managing Member By: /s/Jeffrey J. Collinson --------------------------------------- Jeffrey J. Collinson, President EDWARD BLECH TRUST By: /s/Mordechai Jofen --------------------------------------- Mordechai Jofen, as Sole Trustee /s/Mordechai Jofen -------------------------------------------- Mordechai Jofen COLLINSON HOWE VENTURE PARTNERS, INC. By: /s/Jeffrey J. Collinson --------------------------------------- Jeffrey J. Collinson, President 17 - ------------------------- ------------------------------ CUSIP NO. 015351109 13G PAGE 17 OF 17 --------- ---- ---- - ------------------------- ------------------------------ /s/Jeffrey J. Collinson ----------------------------------------- Jeffrey J. Collinson SCHRODERS INCORPORATED By: /s/Jeffrey J. Collinson ----------------------------------------- Jeffrey J. Collinson Its: Attorney-in-Fact SCHRODER VENTURES LIMITED PARTNERSHIP By: SCHRODER VENTURES MANAGEMENT L.P. Its: General Partner By: SCHRODER VENTURE MANAGERS INC. Its: General Partner By: /s/Peter Everson ----------------------------------------- Peter Everson SCHRODER VENTURES U.S. TRUST By: SCHRODER VENTURE MANAGERS LIMITED Its: Manager By: /s/Peter Everson ----------------------------------------- Peter Everson